Understanding your medication is crucial for its safe and effective use. This enhanced patient information leaflet aims to provide clear insights into Disprelone-D Tablets, helping you grasp the essentials without delving into complex medical jargon.
Product Overview
Brand Name: Disprelone-D Tablets
Generic Name: Prednisolone Sodium Metasulphobenzoate
Pharmaceutical Form: Dispersible Tablets
Manufactured by: Al Andalous for Pharmaceutical Industries
Distributed by: Al Andalous Medical Company Egypt
Composition
Active Ingredient: Prednisolone Sodium Metasulphobenzoate (31.4 mg, equivalent to 20mg Prednisolone base).
Inactive Ingredients: Microcrystalline cellulose, lactose, colloidal silicon dioxide, crosscarmellose sodium, magnesium stearate, cinnamon flavor.
Understanding Disprelone-D
Pharmacological Action
Prednisolone, the active component, functions by reducing inflammation, suppressing the immune system, and managing various conditions.
Pharmacokinetics
Peak Plasma Concentration (Oral Route): Reached within 5 hours.
Protein Binding: 65-91%, decreased in elderly.
Metabolism: Primarily hepatic, with additional metabolism in most tissues.
Half-life (Elimination): 3.6 hours; prolonged in end-stage renal disease.
Biological Half-life: 18-36 hours.
Excretion: Primarily through urine.
Medical Indications
Disprelone-D is prescribed for several conditions, including but not limited to:
Rheumatic Fever
Rheumatoid Arthritis
Gouty Arthritis
Psoriasis Arthropathica
Severe Bronchial Asthma
Allergic States (e.g., drug sensitivity, severe hay fever)
Skin Conditions (e.g., eczema, dermatitis, lupus erythematosus)
Blood Disorders (e.g., anemia, leukemia)
Liver and Bowel Diseases
Severe Infections (short-term therapy with antibiotics)
Endocrine Disorders
Dosage & Administration
Dosage varies based on diagnosis, severity, patient response, and tolerance. Here is a general guide:
Initial Dose: 10-20 mg (up to 60 mg in severe cases) taken in the morning after breakfast.
Maintenance Dose: Usually 5-15 mg daily, but higher doses may be needed.
Dosage may be adjusted over time.
Contraindications
Peptic Ulcer: Glucocorticoids are contraindicated.
Infectious Diseases: Special care needed, especially in tuberculosis. Maintain antituberculosis drug cover.
Diabetes & Mental Disorders: Monitor carefully.
Live Virus Vaccines: Avoid while on Disprelone-D.
Side Effects
Understanding potential side effects is crucial. Common ones include:
Cardiovascular: Edema, hypertension
Central Nervous System: Headache, insomnia, nervousness
Dermatological: Skin redness, hirsutism, urticaria
Metabolic: Increased appetite, weight gain
Gastrointestinal: Abdominal distention, nausea
Musculoskeletal: Arthralgia, muscle weakness
Ocular: Cataracts, glaucoma
Respiratory: Nosebleeds
Miscellaneous: Impaired wound healing
Drug Interactions
Disprelone-D may interact with various drugs. It can increase or decrease the effects of other medications, affecting overall treatment outcomes.
Increased Effects: Anticoagulants, cyclosporine, NSAIDs.
Decreased Effects: Antidiabetic agents, calcitriol, isoniazid.
Altered Corticosteroid Effects: Calcium channel blockers, estrogen derivatives, certain antibiotics.
Pregnancy and Lactation
Pregnancy: Not recommended during pregnancy.
Lactation: Should not be given while breastfeeding.
Precautions and Warnings
Warnings
Prolonged use may lead to adrenal suppression, immune suppression, myopathy, and psychotic disturbances.
Precautions
Cardiovascular Disease: Caution in heart failure patients.
Diabetes: Monitor glucose levels closely.
Gastrointestinal Disease: Use cautiously in GI diseases.
Hepatic Impairment: Caution in patients with liver issues.
Osteoporosis: Contraindicated in osteoporosis patients.
Renal Impairment: Use with caution in renal impairment.
Seizure Disorders: Use cautiously in patients with a history of seizures.
Thyroid Disease: Dosage adjustments may be necessary.
Patient Guidance
Take after meals or with food to minimize GI effects.
Increase dietary intake of certain vitamins and minerals.
Potassium supplementation may be justified for certain cases.
Inform healthcare provider if pregnant, planning pregnancy, or breastfeeding.
If you have diabetes, monitor glucose levels closely.
Be cautious about potential susceptibility to infections.
Report any signs of overdose promptly.
Keep medicines out of reach of children.
This information is a guide and not a substitute for professional medical advice. Always consult your healthcare provider for personalized guidance regarding your health and medication. I apologize for the oversight. The summarized content is longer than the requested 30% of the original text. Let me provide a more concise version that focuses on the main key points:
Disprelone-D Product Characteristics
Trade Name: Disprelone-D Tablets
Generic Name: Prednisolone Sodium Metasulphobenzoate
Form: Dispersible Tablets
Composition: Active Ingredient 31.4 mg Prednisolone, Inactive Ingredients Microcrystalline cellulose, lactose, colloidal silicon dioxide, etc.
Pharmacology & Usage
Action: Reduces inflammation, suppresses the immune system.
Indications: Rheumatoid arthritis, asthma, allergic reactions, skin disorders, blood diseases, liver and bowel conditions.
Dosage & Administration
Dose: Variable, initial 10-20 mg, maintenance 515 mg daily.
Contraindications: Peptic ulcer, infectious diseases, caution in diabetes.
Side Effects: Various, including cardiovascular, central nervous system, gastrointestinal, etc.
Interactions: Influences effects of other medications.
Pregnancy & Precautions
Pregnancy & Lactation: Not recommended.
Warnings: Long-term use may lead to adrenal suppression, immune suppression.
Precautions: Caution in various conditions such as cardiovascular disease, diabetes, gastrointestinal disease, etc.
Patient Guidance
Administration: Take after meals to reduce GI effects.
Supplementation: Consider potassium for specific cases.
Monitoring: Regular monitoring advised, especially for diabetic patients.
Reporting: Promptly report signs of overdose.
Storage: Keep medicines out of reach of children.
DISPRELONE D TABLETS PATIENT INFORMATION LEAFLETتنزيلDISPRELONE D TABLET ديسبيرلون دى اقراص
